Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR

The Benign Prostatic Hyperplasia is one of the common old age problem and alpha adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl selective 1A blocker with better tolerability profile once daily dosing advantage. present study was under taken to establish compatibility a number excipients by using thermo analytical technique viz Thermogravimetry (TG) differential scanning calorimetry (DSC) in formulation. TG DSC both results demonstrated that ethyl cellulose, Gelatin lactose found be incompatible should avoided pharmaceutical preparation.